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Insect calpains

Table 3 Drosophila melanogaster (fruit fly) calpains

Fruit fly calpain gene Longest product gi No. Product name Most similar human calpain Identity (%) Classification
CALPA NP_477047 17137010 CALPA CAPN9 52.1 classical
CALPB NP_524016 28574468 CALPB CAPN9 45.2 classical
CALPC NP_573118 24642465 CALPC CAPN9 30.4 classical
CALPD/SOL NP_476738 45549036 CALPD/SOL CAPN15 54.0 SOL

Table 4 Anopheles gambiae (mosquito) calpains

Mosquito calpain gi No. Proposed name Most similar Drosophila calpain Identity (%) Most similar human calpain Identity (%) Classification
XP_320459 158300576 AgCALPA CALPA 35.6 CAPN2 40.0 classical
XP_001238322 158300574 AgCALPB CALPB 63.9 CAPN9 46.8 classical
XP_552135 118792694 AgCALPB2 CALPB 42.2 CAPN2 39.1 classical
XP_559060 118781597 AgCALPC CALPC 55.8 CAPN9 34.2 classical w/o active site residue
XP_001231066 158296379 AgCALPD CALPD 81.7 CAPN15 53.1 SOL
XP_309874 158288012 AgCALPE CALPD 31.5 CAPN7 49.2 PalB-PalB
XP_320276 158300323 AgCALPF CALPB 29.0 CAPN11 30.0 demi

Fig. 6 Phylogenetic tree and schematic structures of insect calpains.

(A) Phylogenetic tree of Anopheles gambiae and human calpains. The tree was drawn using the neighbor-joining/bootstrap method after aligning all of the sequences using MAFFT v6.240 (strategy: E-INS-i). Drosophila melanogaster (Dm.CALPx) homologs are shown in green letters. (B) Schematic structures.

Abbreviations used for domain names:
CysPc: calpain-like cysteine protease sequence motif defined in the conserved domain database at the National Center for Biotechnology Information (cd00044), which is composed of two protease core domains 1 and 2 (PC1 and PC2)
PC1: protease core domain 1
PC2: protease core domain 2
CBSW: calpain-type beta-sandwich domain (formerly called "C2-domain-like (C2L)" domain)
PEF: penta-EF-hand domain
P-rich: Pro-rich region
DIS: Drosophila-type insertion sequence
MIT: microtubule interacting and transport motif
Zn: Zn-finger motif
SOH: SOL-homology domain

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