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Nematode calpains

Table 5 Caenorhabditis elegans (nematode) calpains

Nematode calpain Ref. seq. Proposed name Most similar human calpain Identity (%) Classification
CLP-1[C06G4.2] NP_498740 CLP-1 CAPN9 49.0 DEK1
CLP-2[T04A8.16] NP_497964 CLP-2 CAPN7 41.2 PalB-PalB
CLP-3[Y47H10A.1] NP_493052 CLP-3 CAPN9 39.2 DEK1
CLP-4[Y39A3CL.5] NP_871643 CLP-4 CAPN8 49.6 DEK1
TRA-3[CLP-5] NP_502751 CLP-5 CAPN5 39.0 PalB-TRA-3
CLP-6[Y77E11A.10] NP_500081 CLP-6 CAPN9 42.7 DEK1
CLP-7[Y77E11A.11] NP_500082 CLP-7 CAPN9 47.0 DEK1
T11A5.6 NP_741604 CLP-8 CAPN15 32.2 SOL
W05G11.4 NP_497130 CLP-9 CAPN15 30.8 SOL
F44F1.3 NP_493327 CLP-10 CAPN15 24.2 SOL
W04A4.4 NP_493397 CLP-11 CAPN15 27.8 SOL/demi
F47F6.9 NP_001022179 CLP-12 CAPN15 22.2 SOL/demi
H25P06.4 NP_492904 CLP-13 CAPN8 28.0 demi
Y53H1B.6 NP_492903 CLP-14 CAPN8 28.0 demi

Fig. 7 Phylogenetic tree and schematic structures of Caenorhabditis elegans calpains.

(A) Phylogenetic tree of C. elegans and human calpains. The tree was drawn using the neighbor-joining/bootstrap method after aligning all the sequences using MAFFT v6.240 (strategy: E-INS-i). (B) Schematic structures.

Abbreviations used for domain names:
CysPc: calpain-like cysteine protease sequence motif defined in the conserved domain database at the National Center for Biotechnology Information (cd00044), which is composed of two protease core domains 1 and 2 (PC1 and PC2).
PC1: protease core domain 1
PC2: protease core domain 2
CBSW: calpain-type beta-sandwich domain (formerly called "C2-domain-like (C2L)" domain)
GR: glycine-rich domain
MIT: microtubule interacting and transport motif
Zn: Zn-finger motif
SOH: SOL-homology domain
CI and CII: conserved regions I and II with unknown function, respectively.

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