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Schistosome calpains

Table 6 Schistosoma mansoni (blood fluke) calpains

Schistosome calpain Proposed name Most similar human calpain Identity (%) Classification
XP_002577797 Sm.CAPN1  CAPN9 30.0 classical
CAPN11 37.2 classical
XP_002579967 Sm.CAPN2 CAPN9 44.3 classical
XP_002571860 Sm.CAPN3 CAPN9 40.9 classical
XP_002574979 Sm.CAPN4 CAPN11 45.1 classical
XP_002574256 Sm.CAPN5 CAPN9 32.4 classical
XP_002578116 Sm.CAPN6 CAPN6 29.4 PalB-TRA-3
XP_002579452 Sm.CAPN7 CAPN7 51.1 PalB-PalB

Fig. 8 Phylogenetic tree and schematic structures of Schistosoma mansoni calpains.

(A) Phylogenetic tree of S. mansoni and human calpains. The tree was drawn using the neighbor-joining/bootstrap method after aligning all the sequences using MAFFT v6.240 (strategy: E-INS-i). (B) Schematic structures.

Abbreviations used for domain names:
CysPc: calpain-like cysteine protease sequence motif defined in the conserved domain database at the National Center for Biotechnology Information (cd00044), which is composed of two protease core domains 1 and 2 (PC1 and PC2).
PC1: protease core domain 1
PC2: protease core domain 2
CBSW: calpain-type beta-sandwich domain (formerly called "C2-domain-like (C2L)" domain)
PEF: penta-EF-hand domain
P-rich: Pro-rich region
DIS: Drosophila-type insertion sequence
MIT: microtubule interacting and transport motif
USP: ubiquitin-specific peptidase

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